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KMID : 0366919940060010010
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Sungkyun Pharmceutical Journal
1994 Volume.6 No. 1 p.10 ~ p.15
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Abstract
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Isolated rat livers were perfused and the membrane potentials of matched periportal and pericentral hepatocytes were determined using glass microelectrodes. Gluconeogenesis and O_2 uptake were increased by glucagon stimulation. While octanol had no effect on gluconeogenesis, it increased the O_2 uptake during glucagon stimulation. With no exogenous substrate, hepatocyte membrane potentials were approximately -27 mV. No gradients were found. Substrate produced hyperpolarization in all hepatocytes, with small but significant gradient produced. Glucagon hyperporlarized homogenously with no gradients across the acinus. Although no changes were found under basal condition, octanol addition resulted in heterogeneity of membrane potential during substrate and glucagon stimulation. Our findings suggest that glucagon induced homogeneity of membrane potential may be mediated at least in part by increased gap junctional coupling.
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